Characterization of Immunomodulating Action of TI-31 on Antibody Response in Mice
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概要
- 論文の詳細を見る
TI-31,at concentrations of 10 and 100μM, suppressed the antibody response to T celldependent (sheep red blood cells, SRBC) and -independent antigens (trinitrophenyl-lipopolysaccharide, TNP-LPS and TNP-Ficoll). The anti-SRBC response was suppressed by TI-31 when T cells were replaced by a supernatant of concanavalin A (Con A)-stimulated spleen cells, indicating the drug had influence on T lymphocytes, B lymphocytes and macrophages. TI-31 augmented the Con Ainduced suppressor T cell (Ts) assessed by anti-SRBC plaque-forming cells response in vitro. The drug (10mg/kg, p. o.) potentiated antigen specific Ts induction in vitro after injection of a high dose of SRBC. The results demonstrate that TI-31 enhanced Ts induction, which resulted in a diminution of antibody formation.
- 公益社団法人日本薬学会の論文
著者
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KOMORIYA Keiji
Pharmacological Research Department, Pharmaceuticals Development Research Laboratories, Teijin Insti
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Yamamoto Itaru
Pharmacological Research Department Teijin Institute For Bio-medical Research Ii : Department Of Imm
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Nagata Ikuo
Pharmacological Research Department Teijin Institute For Bio-medical Research Ii : Department Of Imm
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Komoriya K
Pharmacological Resarch Department Teijin Institute For Bio-medical Research Teijin Ltd.
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TAKESHITA Toru
Pharmacological research Department, Teijin Institute for Bio-medical Research II
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Komoriya Keiji
Pharmacological Research Department Pharmaceuticals Development Research Laboratories Teijin Institu
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Takeshita Toru
Pharmacological Research Department Teijin Institute For Bio-medical Research Ii : Department Of Imm
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