Effect of β-Hydroxybutyrate, a Cerebral Function Improving Agent, on Cerebral Hypoxia, Anoxia and Ischemia in Mice and Rats
スポンサーリンク
概要
- 論文の詳細を見る
Although improving energy metabolism in ischemic brain has been accepted for the treatment of cerebrovascular diseases, administration of glucose, as an energy substrate, would aggravate ischemic brain damage via activating anaerobic glycolysis, which leads to lactate accumulation. β-hydroxybutyrate (BHB) is one of the ketone bodies that can be utilized as an energy source during starvation. The purpose of our study was to define the protective effects of BHB on brain damage induced by hypoxia, anoxia and ischemia. The isotonic solution of BHB administered 30 min before the induction of ischemia at doses over 50 mg · k g −1 · h −1 showed remarkable protective effects against hypoxia and anoxia. BHB administered immediately after a bilateral carotid artery ligation at a dose of 30 mg · kg−1 · h −1 significantly suppressed the elevation of cerebral water and sodium contents as well as maintaining high ATP and low lactate levels. In contrast, glycerin, a hypertonic agent, substantially reduced the water content but did not show any significant effect on other parameters. We demonstrated that BHB, unlike glycerin, when used as an energy substrate in ischemic brain, has protective effects on cerebral hypoxia, anoxia and ischemia-induced metabolic change.
- 社団法人 日本薬理学会の論文
- 2001-10-01
著者
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Hiraide Atsushi
清水製薬
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HIRAIDE ATSUSHI
Department of General Medicine, Osaka University Graduate School of Medicine
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Hiraide Atsushi
Department Of General Medicine Osaka Uiversity Medical School
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Matsui Akira
Equine Science Division Hidaka Training And Research Center Japan Racing Association
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SUZUKI Motohisa
Shimizu Research Laboratories, Reseach and Development Division, Shimizu Pharmaceutical Co , Ltd.
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SUZUKI Mayumi
Shimizu Research Laboratories, Reseach and Development Division, Shimizu Pharmaceutical Co., Ltd.
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SATO Kazunori
Shimizu Research Laboratories, Reseach and Development Division, Shimizu Pharmaceutical Co., Ltd.
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DOHI Sekiko
Shimizu Research Laboratories, Reseach and Development Division, Shimizu Pharmaceutical Co., Ltd.
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SATO Takashi
Shimizu Research Laboratories, Reseach and Development Division, Shimizu Pharmaceutical Co., Ltd.
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MATSUURA Akihiro
Shimizu Research Laboratories, Reseach and Development Division, Shimizu Pharmaceutical Co., Ltd.
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Sato Tosiya
The Institute Of Statistical Mathematics
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Dohi Sekiko
Shimizu Research Laboratories Reseach And Development Division Shimizu Pharmaceutical Co. Ltd.
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Suzuki Mayumi
Department Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Sato Kazunori
Department Of Nuclear Medicine And Radiology Institute Of Development Aging And Cancer Tohoku Univer
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Matsuura A
Amano Pharmaceutical Co. Ltd. Aichi Jpn
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Suzuki Motohisa
Shimizu Research Laboratories Reseach And Development Division Shimizu Pharmaceutical Co Ltd.
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Matsuura Akihiro
Oral Surgery Sapporo Medical University School Of Medicine
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Matsuura Akihiro
Department Of Applied Chemistry Nagoya Institute Of Technology
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Matsuura Akihiro
Shimizu Research Laboratories Reseach And Development Division Shimizu Pharmaceutical Co. Ltd.
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Matsuura Akihiro
Shimizu Research Center Shimizu Pharmaceutical Co. Ltd.
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Miyazaki Akihiro
Department Of Oral Surgery Sapporo Medical University School Of Medicine
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Suzuki Mayumi
Shimizu Research Laboratories Reseach And Development Division Shimizu Pharmaceutical Co Ltd.
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Miyazaki Akihiro
Oral Surgery Sapporo Medical University School Of Medicine
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Matsuura Akihiro
Shimizu Research Center Shimizu Pharmaceutical Co. Ltd
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Hiraide Atsushi
Department Of Gastroenterology And Hepatology Osaka University Graduate School Of Medicine
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Hiraide Atsushi
Department Of Acute Medicine Kinki University Faculty Of Medicine
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Suzuki Mayumi
Shimizu Research Center, Research and Development Division, Shimizu Pharmaceutical Co., Ltd.
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Suzuki Motohisa
Shimizu Research Center, Research and Development Division, Shimizu Pharmaceutical Co., Ltd.
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Sato Kazunori
Shimizu Research Center, Research and Development Division, Shimizu Pharmaceutical Co., Ltd.
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Dohi Sekiko
Shimizu Research Center, Research and Development Division, Shimizu Pharmaceutical Co., Ltd.
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Sato Takashi
Shimizu Research Center, Research and Development Division, Shimizu Pharmaceutical Co., Ltd.
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