Activations of Coagulation and Fibrinolysis Secondary to Bowel Inflammation in Patients with Ulcerative Colitis
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概要
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Background Recent investigations suggest that activation of coagulation and fibrinolysis occurs in patients with ulcerative colitis (UC). However, the role of the hypercoagulable state in UC has not been determined. On the other hand, there are no reports dealing with coagulation in ischemic colitis (IC), in which acute bowel inflammation and reversible vascular occlusion affect the colon. Thus, our aim was to evaluate the hyper states of coagulation and fibrinolysis in UC by comparing activations of coagulation and fibrinolysis in patients with active UC and in those with IC. Methods Twenty-four patients with active UC and 12 patients with IC were studied, with 18 patients with inactive UC serving as controls. We investigated the activation of the coagulation system, including platelet counts, activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT), serum concentrations of von Willebrand factor (vWF), activated factors XII, XI, X, IX, VIII, VII, V, II, fibrinogen, prothrombin fragments 1+2 (F1+2), thrombin-antithrombin complexes (TAT), protein S, protein C, plasminogen, α-2 plasminogen inhibitor (α-2PI) and D-dimer (D-D). Results Median serum vWF concentrations, F1+2, TAT, fibrinogen, activated factor XI, IX, VIII and V were significantly elevated in patients with active UC and IC compared to those in patients with inactive UC. There was no significant difference between active UC and IC patients in the mean values of any of the factors that were measured. Conclusion The results of the present study indicate that the coagulation-fibrinolysis system is activated in patients with active bowel inflammation such as active UC and IC, and that the hyper states of coagulation and fibrinolysis in patients with active UC are secondary to bowel inflammation.
著者
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Otsuki Makoto
Department Of Gastroenterology And Metabolism University Of Occupational And Environmental Health Ja
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Yamasaki Masahiro
Department Of Anatomy Akita University School Of Medicine
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YOSHIKAWA Ichiro
Department of Earth and Planetary Science, The University of Tokyo
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OTSUKI MAKOTO
Department of Gastroenterology and Metabolism, University of Occupational and Environmental Health, Japan, School of Medicine
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Yoshikawa Ichiro
Department of Gastroenterology and Metabolism, University of Occupational and Environmental Health, Japan, School of Medicine
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Kume Keiichiro
Department of Gastroenterology and Metabolism, University of Occupational and Environmental Health, Japan, School of Medicine
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Tashiro Mitsuo
Department of Gastroenterology and Metabolism, University of Occupational and Environmental Health, Japan, School of Medicine
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