Effects of Cyclophosphamide on Allergic Contact Dermatitis
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概要
- 論文の詳細を見る
A 10mg dose of Cyclophosphamide was administered intraperitoneally to guinea pigs for 5 days at various stages of sensitization, and the effects of the drug for allergic contact dermatitis were studied by vascular permeability. This permeability was markedly increased in the group that was sensitized after administration of Cyclophosphamide, but the condition was inhibited in the group given the drug after sensitization but prior to provocation. Histopathological observations were made using indices of epidermic thickening (hypertrophy) and number of epidermic infiltrating cells. A more severe dermatitis was noted in the group given Cyclophosphamide prior to sensitization, as epidermic thickening in the animals in which the lesser concentration of DNCB had been applied, while there was an infiltration of cells in animals to which a higher concentration of DNCB had been given.
- 島根大学の論文
著者
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Yamasaki Masahiro
Department of Sports Sciences, Graduate School of Integrated Arts and Sciences, Hiroshima University
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JIDOI Joji
Department of Dermatology, Shimane Medical University
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TAKAGAKI Kenji
Department of Cardiology,Okayama Red Cross Hospital
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YAMAMOTO Shoso
Department of Dermatology, Faculty of Medicine, Hiroshima University
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Yamasaki Masahiro
Department Of Dermatology Shimane Medical University
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Yamasaki Masahiro
Department Of Anatomy Akita University School Ot Medicine
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Jidoi Joji
Department Of Dermatology Shimane Medical University
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Yamamoto Shoso
Department Of Dermatology Faculty Of Medicine Hiroshima University
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Yamamoto Syoso
Department Of Dermatology Hiroshima University School Of Medicine
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Takagaki Kenji
Department Of Cardiology Okayama Red Cross Hospital
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MOTIZUKI TERUSO
Department of Dermatology, Hiroshima University School of Medicine
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Motizuki Teruso
Department Of Dermatology Hiroshima University School Of Medicine
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Yamasaki Masahiro
Department Of Anatomy Akita University School Of Medicine
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