Effects of Cyclophosphamide on Lymph Nodes and Pyroninophilic Cells
スポンサーリンク
概要
- 論文の詳細を見る
Cyclophosphamide was given intraperitoneally to guinea pigs in a dose of 10mg/day for a period of 5 days and the histological changes were studied on the 1st, 5th and 10th days after the administration. Changes in number of pyroninophilic cells due to DNCB sensitization were also studied. On the 1st day after discontinuation of Cyclophosphamide, the germinal centres, lymph follicles and paracortical areas of the lymph nodes all showed the same degree of cell component loss, but on the 10th day, only the germinal centres had been restored to their normal level, while the other sites showed a delay in recovery. The administration of Cyclophosphamide prior to DNCB sensitization resulted in a greater increase in pyroninophilic cells in the paracortical area of the regional lymph nodes than in the controls, between 7 to 13 days after sensitization. No increase was noted in the group that was given the drug after sensitization. Thus decrease in the lymph node component was accounted for by the B-cells which are susceptible to the effects of Cyclophosphamide, and the increase in pyroninophilic cells was attributed to this marked decrease in B-cells.
- 島根大学の論文
著者
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Yamasaki Masahiro
Department of Sports Sciences, Graduate School of Integrated Arts and Sciences, Hiroshima University
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JIDOI Joji
Department of Dermatology, Shimane Medical University
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TAKAGAKI Kenji
Department of Cardiology,Okayama Red Cross Hospital
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YAMAMOTO Shoso
Department of Dermatology, Faculty of Medicine, Hiroshima University
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Yamasaki Masahiro
Department Of Dermatology Shimane Medical University
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Yamasaki Masahiro
Department Of Anatomy Akita University School Ot Medicine
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Jidoi Joji
Department Of Dermatology Shimane Medical University
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Yamamoto Shoso
Department Of Dermatology Faculty Of Medicine Hiroshima University
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Yamamoto Syoso
Department Of Dermatology Hiroshima University School Of Medicine
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Takagaki Kenji
Department Of Cardiology Okayama Red Cross Hospital
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MOTIZUKI TERUSO
Department of Dermatology, Hiroshima University School of Medicine
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INADA SHUICHI
Department of Dermatology, Hiroshima Prefectural Hospital
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Inada Shuichi
Department Of Dermatology Hiroshima Prefectural Hospital
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Motizuki Teruso
Department Of Dermatology Hiroshima University School Of Medicine
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Yamasaki Masahiro
Department Of Anatomy Akita University School Of Medicine
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