The Effect of Propafenone on Premature Ventricular Contractions (PVC). An Analysis Based on Heart Rate Dependency of PVCs.:An Analysis Based on Heart Rate Dependency of PVCs
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概要
- 論文の詳細を見る
The effect of 450 mg/day propafenone for two weeks on premature ventricular contractions (PVCs) was studied in combination with an assessment of heart rate (HR) dependency of PVCs using Holter ECG monitoring in patients with more than 720 PVCs per day. The PVC-HR correlation was classified into positive (P), bidirectional (B), and flat and negative (FN) correlation groups. The positive group included only patients in whom PVC frequency increased with a heart rate increase, while the bidirectional group included patients with PVCs whose frequency increased at low heart rates and decreased at high heart rates. The FN group contained both flat (PVC frequency was almost fixed regardless of heart rate changes) and negative (PVC frequency decreased as heart rate increased) correlations. The effectiveness of propafenone was 70% in the positive group and 50% in the nonpositive group which included both bidirectional (67%) and FN (0%) groups, using a > 70% PVC reduction as a criterion of efficacy. From this, we concluded that propafenone is effective in patients showing either positive or bidirectional PVC-HR correlation. The coupling interval (CI) of PVCs was also prolonged by propafenone as a whole. The present study suggests that there are differences in the mechanism of PVC development in patients with flat or negative correlation and those with a positive or bidirectional correlation. Thus, this type of analysis contributes to an understanding of the action of antiarrhythmic agents, and may allow the prediction of their efficacy on PVCs.
- International Heart Journal刊行会の論文
著者
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Saikawa Tetsunori
Department Of Cardiovascular Science Faculty Of Medicine Oita University
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Nakagawa Mikiko
Department Of Cardiovascular Science Oita University
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Takakura Takeshi
Department Of Cardiology Health Insurance Nankai Hospital
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Ishida Shuji
Department Of Botany Faculty Of Science Kyoto University
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Sakata Toshiie
Department Of Anatomy Biology And Medicine Faculty Of Medicine Oita University
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Maeda Toshihiro
Department Of Anatomy Of Shiga University Of Medical Science
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Ito Morio
Department Of Laboratory Medicine Medical Callege Of Oita
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Niwa Hiroko
Department of Internal Medicine, Sugimura Memorial Hospital
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Takeshita Yasushi
Department of Internal Medicine, Tsukumi-chuo Hospital
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Sakata Toshiie
Department of Internal Medicine I, Oita Medical School
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Saikawa Tetsunori
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
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Nakagawa Mikiko
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
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Nakagawa Mikiko
Department of Laboratory Medicine, Oita Medical University
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Ito Morio
Department of Health Care Center, Munakata Ishikai-Hospital
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Takeshita Yasushi
Department of Internal Medicine, Tsukumi Central Hospital, Japan
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Takakura Takeshi
Department of Internal Medicine, Health Insurance Nankai Hospital
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Saikawa Tetsunori
Department of Laboratory Medicine, Oita Medical University
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