Expression Pattern of .ALPHA.v.BETA.3 and .ALPHA.v.BETA.5 Integrin mRNA in Mouse Fetal Gonads

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概要

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• The αvβ3 and αvβ5 integrins are known as transmembrane receptors capable of binding to the RGD amino acid peptide sequence. In mouse early gonadogenesis, some proteins containing the RGD sequence are deposited into extracellular space and participate in morphogenesis. We analyzed the expression patterns of the αvβ3 and αvβ5 integrins in mouse developing gonads (10.5-13.5 days post coitum) using whole-mount in situ hybridization. The αv integrin mRNA was homogenously expressed in developing gonadal regions. On the other hand, the β3 integrin mRNA was found only in large and round cells (presumptive germ cells), whereas β5 integrin was localized in gonadal somatic cells, with the exception of coelomic epithelial cells. The β3 integrin-expressed cells were determined to be primordial germ cells because the number of these cells was drastically reduced in busulfan-treated gonads. In this study, we demonstrated that the αvβ3 and αvβ5 integrins are widely localized in the mouse developing gonads and discussed their presumptive functions on mouse gonadogenesis.

• 日本繁殖生物学会の論文

著者

• Tay Tat

  Department Of Veterinary Anatomy University Of Tokyo

• Kanai Yoshiakira

  Department Of Ultrastructural Research The Tokyo Metropolitan Institute Of Medical Science

• KIDOKORO Tomohide

  Department of Veterinary Anatomy, The University of Tokyo

• Kidokoro Tomohide

  Department Of Veterinary Anatomy The University Of Tokyo

• Mizukami Takuo

  Department Of Veterinary Anatomy Graduate School Of Agricultural And Life Sciences The University Of

• Kurohmaru Masamichi

  Department of Veterinary Anatomy

• KUROHMARU Masamichi

  Department of Veterinary Anatomy, The University of Tokyo

• Hayashi Yoshihiro

  Department of Applied Chemistry, Institute of Colloid and Interface Science, Science University of Tokyo

• HAYASHI Yoshihiro

  Department of Global Agricultural Sciences, The University of Tokyo

• ISHII Maki

  Department of Veterinary Anatomy, The University of Tokyo

• MATSUI Toshiyasu

  Department of Veterinary Anatomy, The University of Tokyo

• TAY Tat

  Department of Veterinary Anatomy, The University of Tokyo

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