Biological Effects of Intermittent Radiation in Cultured Tumor Cells : Influence of Fraction Number and Dose Per Fraction
スポンサーリンク
概要
- 論文の詳細を見る
In intensity-modulated radiation therapy (IMRT) and stereotactic irradiation using a linear accelerator, radiation is administered intermittently and one treatment session often requires 30 min or a longer time. The purpose of the present study was to investigate the effect of fractionation and dose per fraction on cell killing by irradiation in intermittent exposure. Murine EMT6 and SCCVII cells were used. The cells were irradiated to a total dose of 8 Gy in 2, 5, 10, 20 and 40 fractions over 15, 30 and 46 min. The cells were also given 8 Gy in a single fraction over 15, 30 and 46 min using lower dose rates (continuous prolonged radiation groups). As compared with the control group receiving a single dose of 8 Gy at 1.55Gy/min, the cell surviving fraction generally increased in groups receiving fractionated or continuous prolonged radiation. There was a general trend for cell survival to increase with the fraction number up to 20 or 40 fractions in both cell lines. The effects of IMRT and linear accelerator radiosurgery given over 15 min or longer may be less than those of 1- or 2-fraction irradiation. There was a trend for radiation effect to decrease with fraction number.
- 日本放射線影響学会の論文
- 2005-12-28
著者
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SHIBAMOTO Yuta
Department of Radiology, Nagoya City University Hospital
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Shibamoto Yuta
Chubu Radiation Oncology Group
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Shibamoto Yuta
Department Of Therapeutic Radiology And Oncology Graduate School Of Medicine Kyoto University
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OGINO Hiroyuki
Chubu Radiation Oncology Group
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SUGIE Chikao
Department of Radiology, Nagoya City University Graduate School of Medical Sciences
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OGINO Hiroyuki
Department of Radiology, Nagoya City University Graduate School of Medical Sciences
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ITO Masato
Department of Radiology, Nagoya City University Graduate School of Medical Sciences
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Ogino Hiroyuki
Department Of Radiology Nagoya City University Graduate School Of Medical Sciences
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Ogino Hiroyuki
Departments Of Radiology Nagoya City University Medical School
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Ito Masato
Department Of Radiology Nagoya City University Graduate School Of Medical Sciences
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Sugie Chikao
Nagoya City Univ. Graduate School Of Medical Sci. Nagoya Jpn
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Sugie Chikao
Department Of Radiology Nagoya City University Graduate School Of Medical Sciences
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Shibamoto Yuta
Department Of Oncology Chest Disease Research Institute Kyoto University
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Ito Masato
Department Of Applied Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Techno
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Shibamoto Yuta
Department of Radiology, Nagoya City University Graduate School of Medical Sciences
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