Simultaneous Analysis of Marrow Fat Fraction and Bone Mineral Density with Modulus and Real Multiple Gradient-echo MRI
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概要
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To evaluate bone status, we developed a method for analyzing fat fraction (FF) of the bone marrow and bone mineral density (BMD) simultaneously using modulus and real multiple gradient-echo (MRM-GRE) sequence. Modulus images of seven gradient-echoes were simultaneously obtained by the MRM-GRE sequence. Real image of the first echo was also reconstructed to differentiate the areas below and above 50 percent FF. T2 ∗ and the initial signal intensities of water and fat were obtained from the parameters of a theoretically fitted formula applied to each echo signal. FF was calculated from the initial signal intensities of water and fat, and BMD was calculated from T2 ∗. FF and BMD were measured in the lumbar vertebral body and tibia of seventeen normal subjects. BMD findings on MRI were compared with those measured by dual-energy X-ray absorptiometry (DXA) . FF on MRI was in good agreement with subject age. A positive correlation was found between BMD of the lumbar vertebrae and age under twenty-five years, but a negative correlation was found over twenty-five years of age. There was a positive correlation between BMD findings on MRI and DXA. The MRM-GRE method allows FF and BMD to be assessed simply, accurately and simultaneously.
著者
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MOTONO Yuko
Division of Health Sciences, Graduate School of Medical Science, Kanazawa University
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MIYATI Tosiaki
Division of Health Sciences, Graduate School of Medical Science, Kanazawa University
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UEDA Yuu
Division of Health Sciences, Graduate School of Medical Science, Kanazawa University
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ARAI Nobuyuki
Department of Radiology, Nagoya City University Hospital
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KASAI Harumasa
Department of Radiology, Nagoya City University Hospital
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HARA Masaki
Department of Radiology, Nagoya City University Hospital
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KAWANO Makoto
Department of Radiology, Nagoya City University Hospital
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SHIBAMOTO Yuta
Department of Radiology, Nagoya City University Hospital
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KAWAMITSU Hideaki
Department of Radiology, Kobe University Hospital
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SUZUKI Yuriko
Philips Medical Systems
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MATSUBARA Kosuke
Division of Health Sciences, Graduate School of Medical Science, Kanazawa University
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Kawano Makoto
Department Of Anesthesia Kagoshima Medical Center
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Arai Nobuyuki
Department Of Physics Graduate School Of Engineering Yokohama National University
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Kawamitsu Hideaki
Department Of Radiology Kobe Graduate School Of Medicine
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Shibamoto Yuta
Department Of Oncology Chest Disease Research Institute Kyoto University
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Hara Masaki
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University:(present) Internationa
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Suzuki Yuriko
Philips Electronics Japan
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Miyati Tosiaki
Division Of Health Sciences Graduate School Of Medical Science Kanazawa University
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