Low-Molecular-Weight Hyaluronan Permeates through Human Intestinal Caco-2 Cell Monolayers via the Paracellular Pathway
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概要
- 論文の詳細を見る
The intestinal permeability of low-molecular-weight hyaluronan (LMW-HA) was investigated by using cultured monolayers of Caco-2 cells. The amount of LMW-HA that permeated the Caco-2 monolayers was measured by a carbazole assay. The permeability of LMW-HA increased inversely with the molecular size and was dose-dependent. The transport was observed to be energy-independent, and was correlated with the tight junction (TJ) permeability. These results suggest that LMW-HA permeated the Caco-2 cell monolayers via the paracellular pathway.
- 社団法人 日本農芸化学会の論文
著者
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MORI Akira
Graduate School of Engineering Sciences, 39, Kyushu University
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Satsu Hideo
Graduate School Of Agricultural And Life Sciences The University Of Tokyo
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Shimizu Makoto
Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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TOTSUKA Mamoru
Graduate School of Agricultural and Life Sciences, The University of Tokyo
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HISADA Nozomi
Graduate School of Agricultural and Life Sciences, The University of Tokyo
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KAMEI Jun-ichi
Kikkoman Co., R Division
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NOZAWA Takashi
Kibun Food Chemifa Co., Ltd.
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