フィラリアおよび糞線虫症と成人T細胞白血病ウイルス感染 : 旧フィラリア流行地・熊本県南部の過疎地における調査

概要

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The birth places of patients with adult T-cell leukemia(ATL) are clustered in the rural coastal areas in Kyushu and South Shikoku. Among several endemic diseases, the geographical distribution of patients with bancroftian filariasis is most similar to that of ATL in japan. In the survey of Goto Islands of Nagasaki Prefecture, we formulated an etiological hypothesis that a combination of repeated exposure to filaria antigen and ATL virus(ATLV) might have played an important role in the etiology of ATL. However, in the present study of Tsunaki-cho in Kumamoto Prefecture where ATL is endemic and patients with filariasis had been commonly observed until 1964, similar results could not be observed. The results obtained in this study could not suggest the consideration that filarial infection in the past might have some promoting effects on ATLV infestation among inhavitants in Tsunaki-cho, because we could not obtain any relationship between filaria and ATLV antibody titers in this time. Many of the inhabitants (19.8%) in Tsunaki-cho were suffered from a kind of fluke worm, Heterophyes heterophyes nocens. However, no relationship between heterophyes and ATLV infection could be also observed.
長崎大学熱帯医学研究所,Institute of Tropical Medicine, Nagasaki Universityの論文
1986-12-27