重症急性膵炎とアフェレシス(<特集>肝・膵疾患とアフェレシス)

概要

論文の詳細を見る
The therapeutic value of apheresis in patients with acute pancreatitis is reviewed. Activated pancreatic enzymes self-digest pancreas in acute severe pancreatitis, then pancreatic proteases, cytokines, or other humoral factors induce remote organ failure. Protease inhibitors inhibit their action on the other hand. Therapeutic apheresis has an effectiveness to decrease those humoral factors. Repeated peritoneal lavage in an early phase of the disease is effective to decrease harmful components in the peritoneal cavity and to prevent organ dysfunction. Plasma exchange decreases humoral factors in the blood and supplies protease inhibitors in the fresh frozen plasma as a substitution fluid. Hemodialysis or continuous arterio-venous hemodiafiltration also decreases serum factors and treats acute renal failure. Acute pancreatitis, as a complication of hemodialysis or CAPD, occurs from the etiological diseases of endo stage renal failure and there is no apparent correlation to the apheresis procedure itself.
日本アフェレシス学会の論文
1997-10-31