グラヤノトキシンIIIの酵素,脂質および蛋白質への影響 : in vitro実験

概要

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The well-known toxic component occuring in ericaceous plant, grayanotoxin III (GTX III) was isolated from the leaves of Leucothoe grayana MAX. GTX III was incubated with normal human serum and creatine phosphokinase (CK) isozymes for 2 h at 37℃. The activities of glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase, leucine aminopeptidase and γ-glutamyl transpeptidase, and the serum levels of triglycerids, cholesterol, β-lipoprotein, total protein and albumin were not affected by the addition of GTX III. But, the activity of CK-MB (from beef heart) was increased by 10.3% (p < 0.05) by the addition of 10 mg/l GTX III (corresponding to 0.4 mg/kg in circulatory serum volume). The activity of CK-BB (from rabbit muscle) was not increased by GTX IIII.
日本生薬学会の論文
1988-09-20