Inhibitory effects of autolysate of Leuconostoc mesenteroides isolated from kimoto on melanogenesis(BREWING AND FOOD TECHNOLOGY)
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the inhibitory effects of the autolysate of Leuconostoc mesenteroides, a lactic acid bacterium isolated from sake mash, on melanogenesis in BI6FO murine melanoma cells and a human skin model. The autolysate: induced a decrease in melanin content in B16FO murine melanoma cells and a 17%, 36%, 41% and 58% decrease in the human skin model by the application of 0.125, 1.25, 6.25, and 12.5 mg/tissue in total; decreased tyrosinase activity to 71%, 46% and 29% of control in B16FO cells with 0.1, 0.2 and 0.4 mg/ml-medium respectively, but did not inhibit tyrosinase activity under cell-free conditions; decreased amount of tyrosinase in a dose-dependent manner from 74% with 0.1 mg/ml to 33% with 0.4 mg/ml; and decreased amount of tyrosinase mRNA to 80-90% with 0.2-0.4 mg/ml-medium. As the decrease in tyrosinase mRNA levels could not fully account for the reduction in protein, we suggest that the autolysate had post-transcriptional effects rather than transcription inhibition. Our results indicate that the autolysate of L. mesenteroides has potential therapeutic use as an effective anti-melanogenic agent.
著者
-
Takahashi Toshinari
General Research Laboratories Of Kiku-masamune Sake Brewing Co.ltd.
-
Mizoguchi Haruhiko
General Research Labolatories Of Kiku-masamune Sake Brewing Co. Ltd.
-
Yoshida Kazutoshi
Hyogo Prefectural Inst. Technol. Kobe Jpn
-
Takahashi Toshinari
General Research Laboratory, Kiku-Masamune Sake Brewing Co. Ltd.
-
Kondo Sayo
General Research Laboratory, Kiku-Masamune Sake Brewing Co. Ltd.
関連論文
- Adsorption Characteristics of Tryptic Fragments of Bovine β-Lactoglobulin on a Stainless Steel Surface
- Fouling and Cleaning of Stainless Steel Surface : Adsorption and Desorption Behavior of Bovine Serum Albumin and Gelatin
- Performance of Protease as a Cleaning Agent for Stainless Steel Surfaces Fouled with Protein
- New Insertion Sequence in Lactobacillus fructivorans Strains Isolated from Spoiled Sake(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Properties of TCA-Insoluble Peptides in Kimoto (Traditional Seed Mash for Sake Brewing) and Conditions for Liberation of the Peptides from Rice Protein
- Isolation of Copper-Tolerant Mutants of Sake Yeast with Defective Peptide Uptake(BREWING AND FOOD TECHNOLOGY)
- Effect of Amino Acids on Peptide Transport in Sake Yeast(Brewing and Food Technology)
- Effect of Cellular Inositol Content on Ethanol Tolerance of Saccharomyces cerevisiae in Sake Brewing(BREWING AND FOOD TECHNOLOGY)
- Increased Alcohol Acetyltransferase Activity by Inositol Limitation in Saccharomyces cerevisiae in Sake Mash
- Increased Ethyl Caproate Production by Inositol Limitation in Saccharomyces cerevisiae
- Influence of Amino Acid Content in Seed Mash on Peptide Uptake by Yeast Cells in Main Mash in Sake Brewing Process
- Properties of the Peptides Liberated from Rice Protein in Sokujo-moto
- Effect of Overexpression of LAS17 on Stress Tolerance and the Stability of Extrachromosomal DNA in Saccharomyces cerevisiae
- Permeability Barrier of the Yeast Plasma Membrane Induced by Ethanol
- Ethanol-Induced Alterations in Lipid Composition of Saccharomyces cerevisiae in the Presence of Exogenous Fatty Acid
- A New Rapid Technique for Detection of Microorganisms Using Bioluminescence and Fluorescence Microscope Method
- Application of a Bioluminescence Method for the Beer Industry : Sensitivity of MicroStar^-RMDS for Detecting Beer-spoilage Bacteria
- Changes in the Number of Colony-Forming Marine Vibrio sp. Cells After Exposure to Shock Pressures in the Presence of Sodium Ascorbate
- The effect of shock pressures on the inactivation of a marine Vibrio sp.
- Lethality of Shock Pressures to a Marine Vibrio sp. Isolated from a Ship's Ballast Water
- Effect of Fatty Acid Saturation in Membrane Lipid Bilayers on Simple Diffusion in the Presence of Ethanol at High Concentrations
- Differences in the Intracellular Lipids of Sake Yeast in Main Mash Seeded Respectively with Two Kinds of Seed Mash : Kimoto and Sokujo-moto
- Isolation and Characterization of Sake Yeast Mutants Deficient in γ-Aminobutyric Acid Utilization in Sake Brewing(BREWING AND FOOD TECHNOLOGY)
- High Fidelity Segregation of a YEp Vector in [cir^0] Strains of the Yeast Saccharomyces cerevisiae
- A Role of Saccharomyces cerevisiae Fatty Acid Activation Protein 4 in Palmitoyl-CoA Pool for Growth in the Presence of Ethanol
- Classification and Identification of Strains of Lactobacillus brevis Based on Electrophoretic Characterization of D-Lactate Dehydrogenase : Relationship between D-Lactate Dehydrogenase and Beer-Spoilage Ability
- Influence of Ras Function of Ethanol Stress Response of Sake Yeast
- Importance of Intact Structure of Cell Wall for a Marine Vibrio sp. Cell to Resistance against Sodium Cholate
- TLR ligands of Lactobacillus sakei LK-117 isolated from seed mash for brewing sake are potent inducers of IL-12(BREWING AND FOOD TECHNOLOGY)
- TLR ligands of Lactobacillus sakei LK-117 isolated from seed mash for brewing sake are potent inducers of IL-12
- Inhibitory Effects of Wasabi Isothiocyanates on Chemical Mediator Release in RBL-2H3 Rat Basophilic Leukemia Cells
- Anti-allergic effect of lactic acid bacteria isolated from seed mash used for brewing sake is not dependent on the total IgE levels(BREWING AND FOOD TECHNOLOGY)
- Inhibitory effects of autolysate of Leuconostoc mesenteroides isolated from kimoto on melanogenesis(BREWING AND FOOD TECHNOLOGY)
- Anti-allergic effect of lactic acid bacteria isolated from seed mash used for brewing sake is not dependent on the total IgE levels
- Inhibitory effects of autolysate of Leuconostoc mesenteroides isolated from kimoto on melanogenesis