ラット口蓋の創傷治癒過程における弾性系線維の形成とbFGF投与の影響

概要

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The purpose of this study was to investigate the elastic system fiber formation after the mucoperiosteal denudation of rat palates, and to evaluate the effect of basic fibroblast growth factor (bFGF) administration on it. A total of 20 male Wistar rats were divided into a control group, a scar formation group, a bFGF group, and a sham group. In the scar formation, the bFGF, and the sham groups, the lateral palatal mucoperiosteum was excised to form scar tissue on the palate. After the application of fibrin glue, the bFGF solution (20μg/10μl) was injected into the operated area in the bFGF group. At 6 weeks postoperatively, the elastic system, fiber formation was evaluated by the immunofluorescence staining of fibrillin-1. The areas which presented a fibrillin-1 positive reaction were measured and compared among the four groups. In the scar formation and sham groups, the fibrillin-1 positive reaction area was significantly larger than in the control and bFGF groups. There were no significant differences in the fibrillin-1 positive reaction area between the control and bFGF groups. The results suggested that the elastic system fiber formation was accelerated in the wound healing process after the mucoperiosteal denudation of rat palates, which might have been controlled by the local administration of bFGF in the palatal mucosa.
福岡歯科大学学会の論文
2012-04-12