免疫調節作用を有する薬物の開発研究(II) : 数種のアーユルヴェーダ薬物のマウスリンパ球幼若化に及ぼす影響について

概要

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In the course of our studies on immunomodulating agents, 13 different crude drugs used in Ayurvedic medicine were tested for their mitogenic activity on the blastogenesis of the lymphocytes from mouse spleen. Of them, a MeOH extract of the latex of Euphorbia antiquorum showed an appreciable stimulatory effect on the blastogenesis of the lymphocytes (mitogenic activity), while a H_2O extract of the bark of Cinnamomum verum showed an inhibitory effect. The stimulatory effect induced by the extract of E. antiquorum was greatly enhanced by the presence of the mitogen, phytohemagglutinin (PHA), but not by the presence of other mitogens, lipopolysaccharide (LPS), phorbol 12-myristate 13-acetate (PMA), concanavalin A (Con A) and pokeweed mitogen (PWM), which suggests that the stimulatory effect of the extract of E. antiquorum is associated with T-cells. By the bio-assay directed fractionation of the latex of E. antiquorum, its potent mitogenic activity was found to be in a less polar fraction of the extract.
日本生薬学会の論文
1989-09-20