B30 ゲル電気泳動を用いたバイオケミカルナノマシニングの加工形状制御法(OS12 ナノ加工と表面機能(2))

概要

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Plastics are regarded as proper materials for microfluidic chips, and, in particular, biodegradable plastics will be more appropriate from the viewpoint of environmental friendliness. In addition, when they are utilized as chip substrate, biochemical machining can be applied. Biochemical machining is a process which utilizes enzymatic biodegradation. For practical use of biochemical machining, it is necessary to develop arbitrary shaped fabrication methods. This paper proposes an application of gel electrophoresis to shape control method of biochemical machining of (poly(L-lactic acid) (PLLA) by enzyme (proteinase K). With current, proteinase K moves in the direction of cathode, and then, the gradient of enzyme concentration occurs in the gel. This gradient generates the difference of degradation amount, depending on position. This result means electrophoresis has feasibility for shape control method for biochemical machining.
2010-11-19