牛黄,人参製剤霊黄参の薬理作用(第4報) : 免疫応答に対する作用

概要

論文の詳細を見る
Reiousan, consisting of bezoar and ginseng, was examined for its effect on immune responses. At 300 mg/kg/day Reiousan promoted the normal phagocytic activity and increased the anti-IgM PFC responses, and at 30 mg/kg/day, it promoted the phagocytic activity suppressed by restrained and water-immersed (RW) stress. At 300 mg/kg/day it trended to suppress the normal and accelerated delayed hypersensitivity (DTH) responses and at 100 mg/kg/day counteracted the RW stress- induced suppression of the DTH response. Furthermore, Reiousan suppressed the complementary titer, and at 30 mg/ml, it induced the cleavage of C3, a component of complements. It also inhibited the Sarcoma 180 tumor formation dose-dependently in mice. Reiousan at 300 mg/kg/day suppressed the type II allergic reaction and trended to suppress the type IV allergic reaction with no effect on the type I and III allergic reactions. These results suggest that Reiousan may have an immunoregulatory activity without activating type I-IV allergic reactions.
1997-02-20