鹿茸,紅参製剤霊鹿参の薬理学的研究(第2報) : 神経系に対する作用

概要

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Reirokusan improved the clinical signs of the experimental allergic encephalomyelitis in rats at doses of 300 and 1000 mg/kg/day p.o. and the signs of the experimental autonomic imbalance in mice, such as the increase in heart rate and the decrease in nociceptive threshold, at 1000 mg/kg/day p.o., and protected mice against the stress-induced decreases of the sexual and the learning behaviours at 300 and 1000 mg/kg/day p.o. and at 1000 mg/kg/day p.o., respectively. Furthermore, it improved the signs of the experimental peripheral neuropathy in rats, such as the decrease in muscle weights of hind-limb, the ataxia of ambulation and the shorting of distance between digits of hind-paw, at 100, 300 and 1000 mg/kg/day p.o., 300 and 1000 mg/kg/day p.o. and at 1000 mg/kg/day p.o, respectively. It also significantly facilitated the neurite outgrowth in the organ culture of the chicken embryonic dorsal root ganglia at a concentration of 16.7 mg/ml, and augmented the facilitation of that outgrowth by NGF at 5 mg/ml. These results suggest that Reirokusan may improve the abnormalities in the nervous system induced by abnormality in the immune system, stress or injury. In paticular, the improvement of the abnormality in the nervous system induced by the injury may be related to the facilitative action of the medicine on the neurite outgrowth.
2000-12-20