紅参,遠志,サフラン,羚羊角,沈香からなる生薬製剤の薬理学的研究

概要

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A crude drug (N-095), containing red ginseng, polygala root, saffron, antelope horn and aloe wood, was studied for its pharmacological effects. N-095 improved the prolongation of escape latency onto the platform in a Morris water maze induced by ibotenic acid injection into the rat brain. N-095 also significantly increased NGF content in the cerebral cortex and the hippocampus of the basal forebrain-lesioned rats induced by ibotenic acid. N-095 also significantly facilitated the neurite outgrowth in the organ culture of the chicken embryonic dorsal root ganglia, and augmented the facilitation of that outgrowth by NGF. Furthermore, N-095 significantly increased NGF secretion in the astrocyte culture of the brain in rat embryo, and improved the decrease in the survival rate of the neuron in the hippocampus in rat embryo brain induced by amyloid β-peptide. N-095 also improved the increase in water content and the abnormalities in sodium, potassium and calcium contents in rat brain induced by freezing. These results suggest that N-095 may protect the brain when it is damaged and improve the memory disorders such as the disruption of spatial cognition and amnesia. Moreover, these effects of N-095 may be partially related to increase the NGF content in the brain and facilitation of neurite outgrowth.
日本生薬学会の論文
2004-02-20