紅参,遠志,サフラン,羚羊角,沈香からなる生薬製剤の薬理学的研究 : 脳血液循環系に対する作用

概要

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A crude drag (N-095), containing red ginseng, polygala root, saffron, antelope horn and aloe wood, was studied for its pharmacological effects, particularly on the brain blood circulation system. In a Morris water maze, N-095 improved the prolongation of escape latency onto the platform and the shortening of swimming time in a quarter part of a round pool, where the platform had been placed, induced by the electroconvulsive shock to mice. N-095 significantly increased regional blood flow in the hippocampus in rat brain. N-095 significantly facilitated the deformability of rat erythrocyte and delayed the thromboembolic death induced by arachidonic acid in mice. N-095 also improved the decrease in ATP content and the increase in lactate content and the rate of lactate to pyruvate (L/P) in mouse brain induced by KCN. These results suggest that N-095 may augment the cerebral function and improve amnesia and memory disorders such as the disruption of spatial cognition by facilitating the cerebral blood circulation system.
日本生薬学会の論文
2004-04-20