葛根黄連黄〓湯エキス顆粒(QK120)の薬理作用

概要

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Pharmacological effects of the granules of Kakkon-oren-ogon-to extract (QK120) on the experimental hypertension, gastric ulcer and cerebral hypoxia were studied. After oral administration of QK120, the systolic blood pressure was depressed, both in the methyrapone heat stress-induced hypertension rats and the spontaneously hypertensive rats, and the serotonin-induced gastric ulcer in rats was prevented. QK120 increased the volume of perfusate through the ear vessels in rabbits and the blood flow in the several organs in rats inducing vasodilation and increases of blood flows in tissues which may cause hypotensive and anti-ulcer effects. Decreases in the duration of KCN-induced coma in mice and elongation of the survival time of NaNO_2-treated hypobaric hypoxia and cerebral hypoxia mice were also observed by oral administration of QK120.
1995-12-20