J0203-2-6 集束超音波によるソナゾイドの破壊実験([J0203-2]ドラッグデリバリーシステム:技術開発と医療応用(2))

概要

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For destroying Sonazoid microbubbles 1 MHz - ultrasound waves was irradiated by employing a concave ultrasound probe with the vibrating diameter of 40 mm and the arithmetic focal length of 80 mm. The probe was set in distilled water at temperature of 25 ℃. A suspension of Sonazoid ultrasound contrast agent diluted with distilled water with the volumetric concentration of 5 % [v/v] was shut in a cuvette which was positioned at x_<c,b> measured from the bottom of the ultrasound probe. It was found that Sonazoid microbubbles were rapidly destroyed and the survival number was reduced to 40 % of the original number at the exposure time of 100 ms. When a cuvette containing suspension of Sonazoid microbubbles was set at the arithmetic focal point, a limited volume of Sonazoid suspension was exposed to the ultrasound waves, resulting in a relatively larger survival number of Sonazoid microbubbles. Sonazoid destruction was observed by taking snapshots using a nano-pulse light with the pulse duration of 180 ns as a light source.
2010-09-04