衝撃波と脂質二重層膜との干渉に関する分子動力学シミュレーション(S24-1 バイオ・ナノ流動ダイナミクス(1),S24 バイオ・ナノ流動ダイナミクス)

概要

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Cell permeabilization using shock waves may be a promising way of introducing macromolecules and small polar molecules into the cytoplasm and may have applications in gene therapy and anticancer drug delivery. The detailed mechanism of the cell permeabilization however is still unclear. To investigate the mechanism, we have performed molecular dynamics (MD) simulations of the interaction of the shock wave impulse with a lipid-bilayer. The MD simulation determined the relationship between the uptake of water molecules into the lipid bilayer and the impulse. The interaction of a shock wave with a lipid bilayer induced a structural change of the bilayer and subsequently increased the fluidity of each molecule. These changes in the bilayer may be an important factor for the mechanism of cell permeabilization using shock waves.
2004-09-04