J0201-1-6 脂質気泡群を含む液体中を伝播する超音波の音響特性(ドラッグデリバリーシステムとその周辺技術の基礎と展開(1))

概要

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In the field of medical engineering, the application of bubbles of nanometer size to Drug Delivery System (DDS) has attracted great attention as the administration of next generation. DDS with bubbles is expected to be a noninvasive clinical treatment. As the transport carrier of DDS, there exists bubble encapsulated in a lipid bilayer, generally called as a lipid bubble. However, dynamic properties of these lipid bubbles are not yet made clear. In this study, acoustic characteristics of lipid bubbles are experimentally investigated. The resonant frequencies of lipid bubbles are evaluated from attenuation of ultrasound pulse propagating through the experimental cell filled with lipid bubble solution. It is found that the attenuation spectrum has two dominant peaks in the frequency range of 1.0 through 14.0 MHz due to the acoustic energy absorbed by lipid bubble with resonant oscillations.
2009-09-12