AM05-17-024 衝撃波で脂質膜に誘起される水孔のMDシミュレーション(生物流体・生体流体5,一般講演)

概要

論文の詳細を見る
Molecular dynamics simulations of water pore formation by shock waves in a phospholipid bilayer were conducted under the initial condition where the bilayer contains water molecules in its hydrophobic region [Koshiyama, K., et al., AIP Conf. Proc, 754, 104-106, (2005)]. The water pore formation was found to depend on the initial concentration of water molecules in the hydrophobic region. The water pore formation process and stability of water pore agreed with other simulation results of pore formation [Marrink, S.J., et al., J. Am. Chem. Soc, 123, 8638-8639, (2001)]. In addition, the stable water pore diameter was ca. 1.9nm that is 5 times larger than the size of 5 fluorouracil typically used in sonoporation experiments.
日本流体力学会の論文
2005-09-05