うつ病の病態生理 : 活動量、R-R間隔の変化の観点から(一般講演D,生理計測)

概要

論文の詳細を見る
Depression is often accompanied with various physical symptoms, especially autonomic nervous system's symptoms such as dizziness when standing, palpitation and stiff shoulders. The object of this study is to estimate physiological state in depression objectively by measurement of motor activity and autonomic nervous system's activity using actigraphy. Motor activity was significantly increased after recovery from depression. The HFnorm, which probably reflects the activity of cardiac vagal nerves, showed a trend of increase. On the other hand, LF/HF, which is the ratio of LF to HF and is thought to be a marker of sympathetic nervous activity decreased significantly after recovery from depression. These findings suggest the possibility that the activity of the sympathetic nerves would be higher and the activity of the vagal nerves system would be lower in depressive states. Furthermore the fractal dimension of the R-R interval power spectrum was decreased significantly lower after recovery from depression. It could be supposed that this fractal dimension has a close relationship to the balance of total autonomic nervous system activity.
バイオメディカル・ファジィ・システム学会の論文
2008-10-11