S0201-1-3 血管内皮細胞貫通チャネルの形成と物質輸送シミュレーション(マイクロ・ナノバイオメカニクス:細胞生物学への接近(1)解析と応用)

概要

論文の詳細を見る
Transendothelial channels, found in continuous endothelia, are patent pores spanning the endothelial cell body from lumen to ablumen. A recent paper indicates that they can be provided with two stomatal diaphragms. This structure is expected to affect macromolecular exchanges on the basis of size. This study examines intracellular membrane transport by transendothelial channels and the influence of the diaphragm. A system of nonlinear differential equations determining the shape of channels is derived based on variational principle. After a 3-D model of the channel was constructed, CFD software PHOENICS resolves a general balance equation, instead of well-known fluid equations. Then it provides blood flow through the transendothelial channel with or without diaphragm.
一般社団法人日本機械学会の論文
2009-09-12