727 細胞内膜動輸送機構の力学的解析

概要

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The vascular endothelial cell vesicles are attached to both luminal and abluminal surfaces of the endothelium and contribute to the transport of specific macromolecules between the exterior environment and the cell through endocytosis or exocytosis. The vesicles mostly have flask-like or chained bead-like shapes, while they appear free within the cytoplasm and are essentially spherical. The large deformation with steep curvature change of the vesicles is considered to be involved in these transport process. In this study, effect of in-plane shear elasticity and outer cytoplasmic membrane in vesicular mechanics in cells is theoretically investigated. A system of nonlinear differential equations is derived according to the variational principle and is reduced to a two point boundary value problem. The equations are solved through the shooting method along with Newton-Raphson and Runge-Kutta method. The computed shape suggests that the effect of in-plane shear elasticity and outer cytoplasmic membrane are significant and these should be taken into account in numerical simulation.
一般社団法人日本機械学会の論文
2000-09-01