20306 せん断流れ場において血液接触面の表面粗さが血球破壊に与える影響(人工臓器と医用工学(2),OS.8 人工臓器と医用工学)

概要

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It is important to clarify the relationship between surface roughness and degree of hemolysis under shear flow conditions in a rotational shear stressor. The threshold for a rapid increase in hemolysis was an arithmetic mean roughness (Ra) of between 0.6 and 0.8 μm, suggesting that hemolysis occurs with high shear stress because of increased surface roughness. However, we did not quantify the increase in shear stress. Here, we aimed to detect the increase in shear stress during rotation of the stressor, using glycerol solution and dextran added bovine blood. As results, shear stress due to surface roughness was closely related to the level of hemolysis, and the threshold value for the hemolysis shifted according to a viscosity of a fluid. Therefore, hemolysis resulting from surface roughness was affected by fluidic environment on the roughened surface.
社団法人日本機械学会の論文
2009-03-05