715 液晶アクティブマスクを用いた DNA チップ合成システムの開発

概要

論文の詳細を見る
Oligonucleotide microarrays, so called "DNA chips" are currently fabricated by a method based on a combination of a photolithographic technique and photochemical synthesis of oligonucleotides composed of photolabile phosphoramidite deoxynucleosides. We have been developing a rapid and flexible synthesis system for making DNA chips with low cost that replace photolithographic masks with a liquid crystal device (LCD) which act as an active mask to control light-directed oligonucleotide synthesis on a chip. In this system, patterns generated on the LCD with a pixel size 18×18μm are replicated onto a substrate on a scale of 1 : 1 using ultraviolet light (365nm) from a high-pressure mercury lamp through a constructed optical system. A 36×36(μm)^2 (2×2pixels) checkerboard pattern was clearly observed by a CCD camera.
社団法人日本機械学会の論文
2003-09-19