対連合記憶における海馬の役割に関する研究 : 難治性側頭葉てんかん患者の検討から

概要

論文の詳細を見る
The aim of this study is to reveal the role of hippocampus in paired associative memory. Subjects were two female patients with refractory left temporal lobe epilepsy who were going to have selective amygdalo-hippocampectomy because of the failure of medical treatment. Epilepsy focus and verbal dominance of these patients were on the left side. We performed the following tests in order to evaluate the function of hippocampus; (1)electric stimulation test of the hippocampus and the amygdaloid body, (2)various memory tests at the pre-and post-surgical points. In these patients, electrodes were implanted into the hippocampus and the amygdaloid body bilaterally, in order to predict memory impairment after surgery. Electrical stimulation was done using these electrodes while performing newly designed paired associative memory tasks (verbal paired associative task, verbal paired non-associative task, visual paired associative task). Only the stimulation of the left hippocampus resulted failure in the verbal paired non-associative memory task in both patients. These two patients were repeatly tested using four kinds of memory test batteries, 2 weeks, 2 months, 1 year, and 2 years after surgery. The change in scores as compared with pre-operative state revealed an inability to recall verbal informations shown by remarkable damage to the paired non-associative memory. According to the above mentioned investigations, functional disruption of the left hippocampus could produce memory deficits in verbal paired non-associative memory task.
東京女子医科大学の論文
2003-05-25

対連合記憶における海馬の役割に関する研究 : 難治性側頭葉てんかん患者の検討から

スポンサーリンク

概要

著者

関連論文

スポンサーリンク