糖尿病と心疾患(<シリーズ>「糖尿病の治療」(10))

概要

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The morbidity and mortality of cardiovascular disease (CVD) are much higher in the diabetic population when compared with the non-diabetic population. Type 2 diabetes confers a two- to four-fold increase in CVD risk. CVD in diabetic patients are characterized by coronary artery diseases, asymptomatic coronary ischemia, heart failure, arrhythmia, and sudden death. These factors lead to unfavorable outcomes in diabetic patients. Metabolic syndrome which consists of obesity and insulin resistance has recently been reported. It is mostly caused by excessive eating and lack of physical activity. Visceral obesity from excessive intra-abdominal fat deposition is characterized by increased exposure of the liver to free fatty acids and adipocytokines produced from visceral fat. The condition has important implications in the pathophysiology of metabolic syndrome. Metabolic syndrome includes glucose intolerance but its diagnosis does not predict diabetes. Whether the treatment of metabolic syndrome differs from the treatment of each individual component of the disorder is not known. Until further research that would confirm the hypothesis, clinicians should evaluate and treat all CVD risk factors without putting too much emphasis on whether a patient meets the criteria for metabolic syndrome.
東京女子医科大学の論文