音韻性錯語・接近現象を認める進行性失語(神経内科学教室岩田誠教授退任記念特別号)

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We reported a case of a 74-year-old, right-handed woman who had progressive aphasia for more than 2 years. Her intelligence and memory function were preserved. As for verbal symptom, her spontaneous speech was fluent, and repetitions and verbal comprehension were intact. She made phonemic errors in spontaneous speech, naming and writing, but she was almost able to correct them by conduite d'approche. She also she had acalculia and slightly executive dysfunction. Brain magnetic resonance imaging showed left, dominantly fronto-temporo-parietal atrophy, and in Tc-99m ECD single photon emission computed tomography, the uptake in the left ventral parietal lobe was reduced. We then thought that this was a case of slowly progressive aphasia proposed by Mesulam. The aphasic patterns of fluent progressive aphasia were often reported as amnesic aphasia and transcortical aphasia including word meaning (Gogi) aphasia, but this case was different from them, and thus rare. There are some cases that are first diagnosed as being slowly progressive aphasia, and later by their symptoms or by autopsy they are revealed to be Pick's disease, Alzheimer disease or corticobasal degeneration. This patient has acalculia and slight excusive dysfunction, so she might also have symptoms of Pick's disease or Alzheimer's disease.
東京女子医科大学の論文
2008-02-25