EFFECT OF MODEST PERIOPERATIVE INTAKE OF IMMUNO-NUTRITION RICH IN ω -3 POLYUNSATURATED FATTY ACIDS ON IL-10 IN ESOPHAGEAL CANCER PATIENTS

概要

論文の詳細を見る
Background Recent trials have shown that perioperative administration of an immuno-enhancing diet can reduce the incidence of infectious complications and shorten hospital stay following elective surgery. The purpose of this study was to evaluate whether a relatively small perioperative intake of ω -3 polyunsaturated fatty acid (PUFA)-rich nutritional supplement modulates postoperative inflammatory responses.Methods Twenty-three patients with esophageal cancer were prospectively randomized into Treatment (n=11) and Control (n=12) groups. The former drank 2 packs (0.4 L) of a liquid diet that was supplemented with ω -3 fatty acids each day for 6 consecutive days prior to esophagectomy, while the latter drank a control liquid. In addition, both groups received postoperative enteral feeding with the same formula. The levels of human leukocyte antigen-DR (HLA-DR), interleukin (IL)-6 and IL-10 were measured, and polymorphonuclear cell and total lymphocyte counts were obtained.Results Plasma IL-10 levels were significantly (p<0.05) higher in the Treatment group than the Control group after beginning supplemental nutrition. By contrast, postoperative IL-6 levels tended to lower in the Treatment group, but the difference did not reach the level of significance.Conclusions Preoperative oral intake of a small amount of ω -3 PUFA-rich nutritional supplement increased postoperative IL-10 expression.
秋田大学の論文