マイクロ波照射下熱電子環状反応を活用したイソキノリン合成と数種の含窒素天然物合成への応用

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During the past two decades, the microwave-assisted synthetic reaction has attracted much attention because of the acceleration of organic reaction, such as the decreasing of the reaction time and/or the increasing of the reaction yield. In pencyclic reaction, the microwave irradiation has been used for Diels-Alder reaction and Claisen rearrangement. However, the application to the electorocyclic reaction has not been reported yet. We describe here the new synthetic method of the isoquinoline nucleus based on the microwave-assisted thermal electrocychc reaction of 1-azahexatnene system involving the benzene double bond. Furthermore, we performed the total synthesis of TMC-120A and B (furoisoquinohne alkaloid), tnspheridine (phenanthndine alkaloid), and scorpinone (2-azaanthraquinone alkaloid) as its applications
福山大学の論文