生理活性天然物合成への6π電子系電子環状反応の活用に関する研究

概要

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We are developing the synthesis of biologically interesting condensed-heteroaromatic compounds, including natural products by the thermal electrocyclic reaction of 6π electron system incorporating the double bond of the principal aromatic or heteroaromatic ring. In this report, we describe three types of electrocyclic eractions as follows; 1)the synthesis of highly-substituted carbazole alkaloids based on the allene-mediated elecrocyclic reaction involving an indole 2, 3-bond, 2)the synthesis of β-carboline alkaloids and isoquinoline-5, 8-quinone alkaloids based on the thermal elecrocyclic reaction of an 1-azahexatriene system involving and indole 2, 3-bond or benzene 1, 2-bond, and 3)the synthesis of new tetracyclic pyrido[2, 3-b]indole, grossularines, based on the thermal electrocyclic of an 2-azahexatriene system including the indole 2, 3-bond.
公益社団法人日本薬学会の論文
2001-07-01