17pD02 準安定リン酸カルシウム水溶液を利用したアパタイト : 高分子複合体の作製(医療と結晶成長,バイオ・有機マテリアルシンポジウム,第35回結晶成長国内会議)

概要

論文の詳細を見る
Various kinds of polymeric materials were modified on their surfaces to be deposited with amorphous calcium phosphate (ACP) nano-particles. The ACP-modified polymers formed a dense and uniform apatite layer on their surfaces within only 6〜24h in metastable calcium phosphate solutions which were supersaturated with respect to apatite. The present process was applicable for not only a flat substrate but a three-dimensional porous material. Adhesive strength between the polymer and the apatite layer was improved up to approximately 6MPa at maximum by changing modification conditions. By a similar process using a laminin-containing calcium phosphate solution, a laminin-immobilized apatite layer was formed on a polymer surface with retaining cell-adhesion property of laminin. In conclusion, the present process using metastable calcium phosphate solutions is useful to prepare apatite-polymer composites with good biocompatibility and biological activity.
日本結晶成長学会の論文
2005-08-17