1031 心筋細胞収縮性におよぼす交感神経活動変化と微小管増減の影響(G02-4 バイオエンジニアリング(4),G02 バイオエンジニアリング)

概要

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Cytoskeleton plays important roles in the arrangement of intracellular organelles, the development of tissue remodeling, and the determination of mechanical properties of the cell. However, it is not understood how the cytoskeleton influence the contraction of myocardial cells. In the present study, the role of microtubule in the contraction of isolated myocardial cells was studied by hyperpolymerizing microtubule with treating paclitaxel and depoymerizing it with colchicine. Stimulation frequency, concentration of isoproterenol,, and concentration of extracellular calcium were altered to simulate the changes in sympathetic nervous activity. Then, the amount of cell shortening, velocity of shortening, and velocity of 50% relengthening were measured. As results, it was indicated that the microtubule acts as a dumper element (viscous component) for cell contraction. In addition to this, it was indicated that the microtubule acts as a resistant element (elastic component) when cell contraction was enhanced with increasing sympathetic nervous activity.
社団法人日本機械学会の論文
2007-09-07