P-9 クロガネモチに含まれるトリテルペン系サポニン類の化粧品有用性評価(ポスター発表の部)

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Seven triterpenoid glycosides and two phenylpropanoid glycosides were isolated from the fruits of Ilex rotunda. These compounds were determined based on UV, MS, IR ^1H-NMR, ^<13>C-NMR and 2D-NMR spectroscopic data as 3-O-β-glucuronopyranosyl oleanolic acid [1], 3-O-β-glucuronopyranosyl-olean-12-ene-28-oic acid 28-O-β-glucopyranoside [2], 3-O-β-glucuronopyranosyl-23-hydroxyl methyl olean-12-ene-28-oic acid [3], 23-hydroxyl methyl olean-12-ene-28-oic acid [4], 3-O-β-glucuropyranosyl-19-O-β-glucopyranosyl-23-hydroxyl methyl olean-12-ene-28-oic acid [5], 3-O-β-glucuronopyranosyl-19-hydroxy-23-hydroxyl methyl olean- 12-ene-28-oic acid 28-O-β-glucopyranoside [6], 19-hydroxy-olean 12-ene-28-oic acid [7], syringin [8] and chlorogenic acid [9]. And we examined their superoxide scavenging activity and tyrosinase inhibitory activity (Step 1 as L-Tyrosine substrate; Step 2 as L-DOPA substrate), and their compounds investigated for cosmetic use. As a result, for superoxide scavenging activity, the 1-butanol extract and aqueous phase part were good activity of 69.30 and 72.22%, respectively. For tyrosinase inhibitory activity, the 1-butanol extract, good inhibition of 45.05% of Step 1 (L-Tyrosine substrate) was noted. Melanin inhibition and cytotoxicity were examined by using cultured B16 melanoma cells. More than 60% melanin inhibition was observed in the 1-Hexan extract, and methanol eluate of an Amberlite XAD-2. In addition, remarkable melanin inhibitions were found in [1] and [5] which are those isolation compounds. Among these isolated compounds, [5] is a new triterpenoid.
2008-09-01

P-9 クロガネモチに含まれるトリテルペン系サポニン類の化粧品有用性評価(ポスター発表の部)

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