P-10 電解合成法・タリウム酸化法を駆使したイソジチロシン類の全合成研究(ポスター発表の部)

概要

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The diaryl ether is the common key structure for a variety of isodityrosine-class natural products, such as vancomycin, K-13, and OF-4949. These natural products exhibit a wide range of biological activity. Therefore, synthetic studies of natural products carrying the diaryl ether moieties have been reported by many synthetic chemists around the world. Our laboratory has studied application of oxidative phenolic coupling reaction to biomimetic synthesis of a wide range of natural products, such as simple isodityrosines and complicated cyclic peptides. Anodic oxidation and thallium (III) salt oxidation have been investigated in particular. Anodic oxidation is an extremely mild and safety method, since it is usually performed at ambient temperature under neutral conditions, without use of toxic metal oxidants. On the other hand, thallium (III) oxidation is a useful one in the synthesis of highly strained cyclic diaryl ether compounds. In this presentation, related to the two methods mentioned above, applications of electro-organic synthesis for wide range of conversions including direct/indirect anodic oxidation and indirect cathodic reduction, as well as basic study of electrochemical activation of thallium ion in catalytic system, will be discussed.
天然有機化合物討論会の論文
2008-09-01