Current Topics in Molecular Biotechnology of a Koji Mold, Aspergillus oryzae(Recent Topics of the Agricultunal Biological Science in Tohoku University)
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概要
- 論文の詳細を見る
Aspergillus oryzae is an important filamentous fungus in Japanese fermentation industries and produces a large amount of starch-degrading enzymes, whose gene expressions are regulated by a transcription activator AmyR. We have recently found a gene cluster highly homologous to the yeast maltose-utilizing cluster and showed that expression of the cluster genes is independent on AmyR but is involved in assimilating maltose, a product by starch degradation. In this article are described structural features and expression profiles of the maltose-utilizing cluster genes in A. oryzae. On the other hand, A. oryzae has been expected as a favorable host microorganism for heterologous protein production. In order to understand the bottlenecks for hyperproduction of heterologous proteins in A. oryzae, we have investigated the cellular responses using the mutated α-mannosidase of Aspergillus saitoi as a model protein. Interestingly, the mutated α-mannosidase was secreted as a hyperglycosylated form when overexpressed.
- 東北大学の論文
著者
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Shintani Takahiro
Laboratory Of Bioindustrial Genomics Graduate School Of Agricultural Science Tohoku University
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GOMI Katsuya
Laboratory of Bioindustrial Genomics, Graduate School of Agricultural Science, Tohoku University
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Gomi Katsuya
Laboratory Of Bioindustrial Genomics Department Of Bioindustrial Informatics And Genomics Graduate S
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Gomi Katsuya
Dep. Of Bioindustrial Informatics And Genomics Graduate School Of Agricultural Sci. Tohoku Univ.
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Gomi Katsuya
Laboratory Of Bioindustrial Cenomics Graduate School Of Agricultural Science Tohoku University
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Shintani Takahiro
Laboratory Of Bioindustrial Cenomics Graduate School Of Agricultural Science Tohoku University
関連論文
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- Current Topics in Molecular Biotechnology of a Koji Mold, Aspergillus oryzae(Recent Topics of the Agricultunal Biological Science in Tohoku University)
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