Experimental Study on the Effect of the Steroid on Mucosal Damage by Ethanol Injection

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概要

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• Although 70% ethanol has an excellent reduction effect on the mucosal tissue volume, the superficial mucosal damage has been often observed contrary to the intention of clinicians when the present method, i.e., "submucosal ethanol injection therapy" is applied to the various types of mucosal diseases. The modification of injection devices or the improvement on the injection solution or both is probably required to dissolve this problem. In this study, to know whether or not the relief of the secondary inflammation reaction derived by 70% ethanol injection meets to attain the purpose for improving the safety of the injection solution, we contrived a combining formula that contains 70% ethanol and a steroidal agent with an excellent antiinflammatory action (that is, E/S mixture) and performed an experimental study on the effect of it. After the 70% ethanol was applied to the submucosa of the left palatine arch and the E/S mixture containing betamethasone(Rinderon^[○!R]) with several different concentrations per group to the submucosa of the right palatine arch for the same guinea pigs, the change of the local mucosa was observed macroscopically and histopathologically with passage of time. Within the range of concentrations of betamethasone used, the E/S mixture reduced the secondary inflammatory reaction that frequently caused the tissue damage spreading to the mucosal epithelium and exhibited an approximately same volume reduction effect on the palatine arch mucosa as that observed after the sole application of the 70% ethanol. Up to the maximum concentration of approximately 0.12%, the effect of betamethasone increased in a concentration dependent manner. In the future clinical applications, we strongly recommend "submucosal ethanol/steroid(E/S) injection therapy" in place of "submucosal ethanol(E) injection therapy" from the viewpoints of safety, stability and therapeutic efficacy.

• 愛知医科大学の論文

著者

• KIMURA Masaru

  Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University

• SATO Hiroaki

  Department of Internal Medicine, Wakayama Medical University Kihoku Hospital

• NAKAYAMA Meiho

  Department of Otorhinolaryngology, Aichi Medical University

• INAFUKU Shigeru

  Department of Otolaryngology, Aichi Medical University School of Medicine

• Wu Men-dar

  Department Of Otorhinolaryngology Aichi Medical University School Of Medicine

• Sato Hiroaki

  Department Of Biosystem Management Division Of Environmental Conservation Graduate School Of Environ

• Kimura Masaru

  Department Of Anatomy Aichi Medical University School Of Medicine

• Nakayama Meiho

  Department Of Otorhinolaryngology Aichi Medical University School Of Medicine

• Nakayama Meiho

  Department Of Otolaryngology Aichi Medical University

• TAGUCHI AIKO

  Department of Otorhinolaryngology, Aichi Medical University School of Medicine

• Taguchi Aiko

  Department Of Otorhinolaryngology Aichi Medical University School Of Medicine

• Inafuku Shigeru

  Department Of Otorhinolaryngology Aichi Medical University School Of Medicine

• Inafuku Shigeru

  Department Of Otolaryngology Aichi Medical University School Of Medicine

• Kimura Masaru

  Department Of Anatcmy Aichi Medical University

• Sato Hiroaki

  Department Of Otorhinolaryngology Aichi Medical University School Of Medicine

• Sato Hiroaki

  Department Of Agricultural Chemistry Kyushu University

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