Experimental Petit Mal-Like Seizure Induced by Microinjection of Kainic Acid Into the Unilateral Mediodorsal Nucleus of the Thalamus
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概要
- 論文の詳細を見る
The mediodorsal nucleus (MD) of the thalamus has reciprocal projections with the frontal cortex and limbic system, and may be involved in absence seizures. Kainic acid was injected into the left MD of Wistar rats, and behavior and electroencephalography were monitored for 24 hours, then continued intermittently for 8 weeks. The rat brains were then examined histologically. Brain metabolic changes were also investigated by intravenous injection of 100 μCi/kg of [^<14>C]2-deoxyglucose to measure local cerebral glucose metabolism. Bilateral synchronous spike and wave complexes appeared almost 2 hours after kainic acid injection, and the waveforms continued for about 5-7 hours in the bilateral MDs, ipsilateral sensorimotor cortex, and basolateral nucleus of the amygdala. The associated behavioral changes were mainly those of behavioral arrest and staring, associated with occasional limbic seizures. Clear metabolic increases were found in the ipsilateral frontal cortex, hippocampus, and amygdala. The present results suggest that the MD was involved in both the mechanism of spike and wave complexes in the bilateral frontal cortices, and in seizure propagation to the limbic system. Consequently, kainic acid-induced MD seizure is associated with significant cognitive impairment and may explain the mechanism of petit mal seizure.
- 社団法人 日本脳神経外科学会の論文
- 2008-07-15
著者
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HASHIZUME Kiyotaka
Department of Neurosurgery, Asahikawa Medical College
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TANAKA Tatsuya
Department of Neurosurgery, Asahikawa Medical College
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Takayama Teruhiko
金沢大学 医学系研究科保健学
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HORI Tomokatsu
Department of Neurosurgery, Tokyo Women's Medical University
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URINO Tomoyuki
Department of Neurosurgery, Tokyo Women's Medical University
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Urino Tomoyuki
Department Of Neurosurgery Tokyo Women's Medical University
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Hashizume Kiyotaka
Department Of Neurosurgery Asahikawa Medical College
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Hashizume Kiyotaka
Department Of Neurosurgery Asahikawa Medical Collage
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Kato Koichi
Department Of Neurosurgery Tokyo Women's Medical University
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Hori Tomokatsu
Department Of Neurosurgery Tokyo Women's Medical University
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Tanaka Tatsuya
Department Of Neurosurgery Asahikawa Medical Collage
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TSUDA Hiroshige
Department of Neurosurgery, Asahikawa Medical College
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YOSHIDA Katsunari
Department of Neurosurgery, Asahikawa Medical College
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Hori Tomokatsu
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo.
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Hori Tomokatsu
Department Of Neurosurgery Institute Of Clinical Neurology Tokyo Women's Medical University
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Tsuda Hiroshige
Department Of Neurosurgery Asahikawa Medical College
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Yoshida Katsunari
Department Of Neurosurgery Asahikawa Medical College
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Higa Takashi
Department Of Neurosurgery Neurological Institute Tokyo Women's Medical University
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Hori Tomokatsu
Department Of Neurosurgery Tokyo Woman's Medical University
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Kato Koichi
Department Of Biology Graduate School Of Natural Sciences Nagoya City University
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HORI Tomokatsu
Department of Neurosurgery, Tokyo Women's Medical University
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Tanaka Tatsuya
Department of Electrical & Electronics Engineering, Fukui University, 3-9-1 Bunkyo, Fukui 910-8507, Japan
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