CHANGES IN THE CONCENTRATIONS OF PROSTAGLANDINS E AND F IN THE UTERO-PLACENTAL TISSUES OF LATE PREGNANT RABBIT AFTER THE ADMINISTRATION OF OXYTOCIN OR PROSTAGLANDIN F_<2α>
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概要
- 論文の詳細を見る
子宮収縮物質oxytocinおよびprostaglandin (PG) F_<2α>を投与した際の, 妊娠末期子宮胎盤系組織中のPGEおよびPGFの局所濃度変化を家兎を用いて調べた. 実験材料は妊娠26日, 27日, 28日目の家兎それぞれ5羽ずつであつた. ネンプタール静脈麻酔下に片方の子宮角を取り出し対照とした. 同妊娠時期の家兎2羽にPGF_<2α> 3,000μg, 2羽にoxytocin 10μg, 1羽に生理食塩水1mlを静脈内投与し, 10分後に残側の子宮角を摘出した. 子宮筋, 胎盤胎児面, 胎盤母体面, 壁脱落膜, 羊膜を分離し, 各組織からPGEとPGFを抽出し, 濃度をラジオイムノアッセイで測定した. 組織中のPGE濃度は胎盤母体面において, PGF濃度は脱落膜においてそれぞれ最も高い値を示した. 羊膜中のPGEは, PGF_<2α>, oxytocinのいずれの投与によつても, 有意に減少した. 子宮筋のPGF濃度はPGF_<2α>投与によって有意に増加し, 増加率は妊娠日数が進むにつれて上昇した. しかし, oxytocin投与ではこのような増加はみられなかつた. 以上より, 子宮胎盤組織中のPGE, PGFの局所濃度は外因性のPGF_<2α>およびoxytocin によつて特有の変化をすることがわかつた.
- 社団法人日本産科婦人科学会の論文
- 1988-01-01
著者
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NAGATA Ichiro
Department of Obstetrics and Gynecology, National Defense Medical College
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Nagata Ichiro
防衛医科大学校
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Nagata I
Department Of Obstetrics And Gynecology Natinal Dfense Medical College
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Furuya Kenichi
Department of Obstetrics and Gynecology, National Defense Medical College
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Kato Koichi
Department Of Neurosurgery Tokyo Women's Medical University
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Furuya Kenichi
Department Of Obstetrics And Gynecology National Defense Medical College
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Nagata Ichiro
National Defense Medical Collage
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Nagata Ichiro
Department Of Obstetrics And Gynecology Natinal Dfense Medical College
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MAKIMURA Noriko
Department of Obstetrics and Gynecology, National Defense Medical College
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SEKI Katsuyoshi
Department of Obstetrics and Gynecology, National Defense Medical College
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Furuya Kenichi
Departmen T Of Obstetrics An D Gynecology Natio Nal Defense Medical College
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Nagata Ichiro
Departmen T Of Obstetrics An D Gynecology Natio Nal Defense Medical College
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Kato K
Department Of Obstetrics And Gynecology National Defense Medical College
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Seki Katsuyoshi
Department Of Obstetrics And Gynecology National Defense Medical College
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Seki Katsuyoshi
Departmelet Of Obsteirics Aud Gynecology National Defense Medical College
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Makimura Noriko
Department Of Obstetrics And Gynecology National Defense Medical College
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Furuya Kenichi
Department Of Gynaecologic Oncology Saitama Medical University International Medical Center Comprehe
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Furuya Kenichi
Gyn National Defense Medical College
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Makimura Noriko
Gyn National Defense Medical College
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Kato Koichi
Department Of Biology Graduate School Of Natural Sciences Nagoya City University
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