Effects of Naloxone on Prolactin-secreting Pituitary Adenomas
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概要
- 論文の詳細を見る
The investigators assessed the effects of the opioid antagonist naloxone on anterior pituitary hormone release in hyperprolactinemic females with pituitary microadenoma (n = 6) and macroadenoma (n = 7). In those with microadenoma, intravenous bolus injection of naloxone significantly increased serum luteinizing hormone (LH) concentrations but had no significant effect on serum prolactin (PRL), follicle-stimulating hormone, and thyroid-stimulating hormone concentrations. In patients with macroadenoma, naloxone significantly decreased serum LH and serum PRL concentrations. The response of LH to naloxone differed considerably between the two groups of patients. The results suggest that LH and PRL secretion is influenced by changes in endogenous opiates and in gonadotropin-releasing hormone and PRL inhibitory factor due to hypothalamic dysfunction.
- 日本脳神経外科学会の論文
- 1990-02-15
著者
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SHIMA Katsuji
Department of Neurosurgery, National Defense Medical College
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SEKI Katsuyoshi
Department of Obstetrics and Gynecology, National Defense Medical College
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Shima Katsuji
Department Of Neurosurgery National Defense Medical College
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Shima Katsuji
Departments Of Neurosurgery National Defense Medical College
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CHIGASAKI Hiroo
Department of Neurosurgery, University of Tokyo
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Seki Katsuyoshi
Departments Of Obstetrics And Gynecology National Defense Medical College
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Seki Katsuyoshi
Departmelet Of Obsteirics Aud Gynecology National Defense Medical College
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Chigasaki Hiroo
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo
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Chigasaki Hiroo
Departments Of Neurosurgery National Defense Medical College
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