59(P27) Thalictrum 起源のサイクロアルタン配糖体に関する研究(ポスター発表の部)
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概要
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The genus Thalictrum plants grow widely in Japan. Thalictri Herba (dried whole plants of Thalictrum sp.) called Takatogusa has been used as a folk medicine for treating stomachdisorders in Nagano Prefecture. We previously reported the structural characterization of ten new cycloartane glycosides, among which were obtained thalictosides A and C from the fresh aerial parts of Thalictrum thunbergii D.C., cultivated in the Botanical Garden of Tokushima University and thalictosides I, II, III, IV, V, IX, XII and XIII from Thalictri Herba. In our extended search for cycloartane type glycosides, we have now isolated three cycloartane glycosides from the dried aerial parts of Thalictrum thunbergii D.C., which was cultivated in Nagano Prefecture. The structures were established by using 2D NMR techniques (^1H-^1H COSY, HMQC, HMBC, NOESY and TOCSY). Three cycloartane type glycosides designated thalictosides D (1), E (2) and F (3) were novel structure possessing a five-membered ring, which is constructed by a C-C bond between C-21 and C-24, and bisdesmosides at C-3 and C-22. The effects of thalictosides A, C, I, II, III and IV on proliferation of mouse lymphocytes stimulated with mitogens such as concanavalin A (Con A) and lipopolysaccharide (LPS) were examined. Among them, thalictosides I, II, III and IV were found to exhibit the immunosuppressive activity. This examination suggested that the presence of the five-membered ring, which was constructed by a epoxy bond between C-21 and C-23, at the side chain were required for the immunosuppressive activity. Thalictosides I, II, III, IV, XII and XIII, possessing a five-membered ring, were examined for immunosuppressive activity on mouse allogenic mixed lymphocyte reaction (MRL) in vitro. As a results, the activity of the (S)-isomers at C-21 were greater than that of the (R)-isomers at C-21. Moreover the activity of the disaccharide group was greater than that the trisaccharide group and the hydroxyl group at C-24 was depressed the activity.
- 天然有機化合物討論会の論文
- 1999-09-01
著者
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野原 稔弘
熊本大学薬学部
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野原 稔弘
熊本大学 医薬
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野原 稔弘
崇城大薬
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吉満 斉
九州共立大工
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野原 稔弘
熊本大薬
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西田 真紀子
九州共立大工
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野原 稔弘
熊本大 大学院 医学薬学研究部
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吉満 斉
九州共立大・工
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野原 稔弘
能本大学薬学部
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