Studies on Lens-Aldose-Reductase Inhibitor in Medicinal Plants II. : Active Constituents of Monochasma savatierii FRANCH. et MAXIM.

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概要

• 論文の詳細を見る

• The 70% acetone extract of Monochasma savatierii FRANCH. et MAXIM. showed very strong inhibition of rabbit lens aldose reductase (AR). From the active fraction, five iridoid glucosides along with the two phenolic glycosides, acteoside and dehydroacteoside, have been isolated. Among them, acteoside showed the highest activity, being about 2.5 times more potent than baicalein, a known natural inhibitor of AR (IC_<50>=9.8×10^<-7>_M). Demethylmussaenoside and 7-O-acetyl-8-epi-loganic acid, which are iridoid glucosides, had weak inhibitory activity.

• 社団法人日本薬学会の論文
• 1989-11-25

著者

• 野原 稔弘

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 神田 博史

  Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine

• 田中 昭

  Faculty Of Pharmaceutical Sciences Josai University

• 矢原 正治

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 田中 誠司

  Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine

• 山岡 康利

  Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine

• 山岡 康利

  Institute Of Pharmaceutical Sciences School Of Medicine Hiroshima University

• 谷本 剛

  Division of Biological Chemistry and Reference Standards, National Institute of Hygienic Sciences

• 田中 昭

  Division of Biological Chemistry and Reference Standards, National Institute of Hygienic Sciences

• 野原 稔弘

  熊本大学 医薬

• 野原 稔弘

  崇城大薬

• 野原 稔弘

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 神田 博史

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

• 神田 博史

  広島大学医学部附属薬用植物園

• 矢原 正治

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 谷本 剛

  Division Of Biological Chemistry And Biologicals National Institute Of Hygienic Sciences

• 谷本 剛

  National Institute Of Hygienic Sciences

• 田中 誠司

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

• 神田 博史

  広島大 大学院医歯薬学総合研究科 薬用植物園

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