10 オニヒトデより得られる新スフィンゴ糖脂質Acanthaganglioside類の単離と構造(ポスター発表の部)

概要

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In the continuation of the previous studies, isolation and structure elucidations of the gangliosides of Acanthaster planci were conducted with the object of searching for the biologically active compound. A water-soluble lipid fraction, which was obtained by fractionation with organic solvents of the chloroform-methanol extract of A. planci, was separated with reversed phase followed by normal phase column chromatography to give two molecular species of ganglioside(AG-2 and AG-3). On thebase of chemical and spectral evidences, AG-2 and AG-3 were characterized as penta- and hexaglycoside of ceramide consisted of heterogeneous phytosphingisine and 2-hydroxy fatty acid as shown in Fig.3 and 5. By means of preparative separation using reversed phase HPLC, five major compounds acanthaganglioside A(1)〜E(5) were isolated in the pure state from AG-2 and AG-3, and they were asigned as shown in Fig.3 and 5. The islation of these pure gangliosides from starfishes is the first one ever reported. Moreover, these sugar moieties is unique in that neuraminic acid is combined with 4-hydroxy group of galactopyranose unit.
天然有機化合物討論会の論文
1988-09-26