73(PB2-3) パラオ海域の海綿から得られたアルドース還元酵素阻害物質(ポスター発表の部)

概要

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Large number of pharmacologically active natural products have been isolated from the marine organisms. Since 1981, we have carried out the investigations of pharmacologically active compounds from marine organisms forcusing on sponges which collected in southern Pacific water such as Australia, Okinawa and Palau. We isolated many pharmacologically active compounds such as cytotoxic compounds, vaso-dilative compounds, enzyme inhibitors and platelet agregation inhibitors from the marine invertebrates. In this paper, we surveyed the Aldose Reductase Inhibitors out of 150 marine sponges from Palauan sea and we newly isolated sulfated furano-sesterterpenoid(1) from 100% EtOH extracts of Hippospongia sp. which showed potent inhibiting activity of rat aldose reductase(IC_<50>1 × 10^<-5>M). Structure elucidation was carried out by spectroscopic studies and chemically degradation.
天然有機化合物討論会の論文
1987-07-25